How to Use The Ordinary Argireline 10%: Order, Pairings & Results
Forehead lines, crow’s feet and the crease between the brows often lead to the same question: where does a targeted peptide serum fit into a normal routine? The Ordinary Argireline Solution 10% is a lightweight, water-based option for the appearance of expression lines. A clear order of application makes it easier to use consistently.
What Argireline is designed to target
Acetyl Hexapeptide-8 is the peptide behind the Argireline name. The formulation focuses on facial areas where expressions create visible folds, including the forehead, outer-eye area, “11” lines and smile lines. Think focused daily skincare rather than an instant change to facial volume.
A simple morning and evening routine
- Cleanse. Start with a gentle cleanser and clean skin.
- Apply a few drops. Dispense into your hands and press a thin layer onto targeted areas, keeping clear of the eyes. The brand permits targeted or full-face use.
- Follow with heavier skincare. Apply compatible serums as needed, then moisturizer.
- Use sunscreen in the morning. Argireline is not a sunscreen.
Keep these ingredients in another routine
The brand’s current guidance says not to combine Argireline in the same AM or PM routine with direct acids, direct vitamin C, resveratrol and ferulic acid, salicylic acid or its Multi-Antioxidant Radiance Serum. Check the complete formula of each product, rather than judging compatibility only by its headline ingredient.
Can it sit beside retinol?
In its official answers on Ulta, The Ordinary says to apply Argireline before one of its retinoids. Introduce one new product at a time and follow both labels. Prescription treatments and routines involving other brands need individual guidance.
Argireline or hyaluronic acid?
Choose by the concern you want to address. Argireline is focused on the appearance of expression lines. Hyaluronic Acid 2% + B5 with Ceramides is focused on hydration and moisture-barrier support. Keep moisturizer in your routine whichever serum you choose.
Set a realistic review point
The Ordinary’s product guide reports improvement across four expression-line areas after two weeks of testing. It also advises that visible improvement may take several weeks. Results vary, and a topical serum does not duplicate an injectable treatment. Keep your routine consistent and assess your skin under similar lighting.
Before your first application
Patch-test first. Use only on unbroken skin, avoid eye contact and keep out of reach of children. If irritation occurs, rinse off, stop use and consult a physician. Always read the current directions and ingredient list on the bottle you receive.
Explore The Ordinary Argireline Solution 10% — 30 ml. One bottle is available with free tracked delivery to the USA and Canada; estimated delivery is 7–15 business days.
Sources checked November 5, 2026: The Ordinary product directions and compatibility; The Ordinary Argireline guide; official brand answers on Ulta. Formulas and directions may change; check your packaging.